ASD Closure in Structural Heart Disease

Curr Cardiol Rep. 2018 Apr 17;20(6):37. doi: 10.1007/s11886-018-0983-x.


Purpose of review: While the safety and efficacy of percutaneous ASD closure has been established, new data have recently emerged regarding the negative impact of residual iatrogenic ASD (iASD) following left heart structural interventions. Additionally, new devices with potential advantages have recently been studied. We will review here the potential indications for closure of iASD along with new generation closure devices and potential late complications requiring long-term follow-up.

Recent findings: With the expansion of left-heart structural interventions and large-bore transseptal access, there has been growing experience gained with management of residual iASD. Some recently published reports have implicated residual iASD after these procedures as a potential source of diminished clinical outcomes and mortality. Additionally, recent trials investigating new generation closure devices as well as expanding knowledge regarding late complications of percutaneous ASD closure have been published. While percutaneous ASD closure is no longer a novel approach to managing septal defects, there are several contemporary issues related to residual iASD following large-bore transseptal access and new generation devices which serve as an impetus for this review. Ongoing attention to potential late complications and decreasing their incidence with ongoing study is clearly needed.

Keywords: Atrial septal defect (ASD); Congenital heart disease; Iatrogenic ASD; Septal defect closure; Structural heart disease intervention.

Publication types

  • Review

MeSH terms

  • Atrial Fibrillation / complications*
  • Atrial Fibrillation / physiopathology
  • Cardiac Catheterization / adverse effects*
  • Cardiac Catheterization / instrumentation
  • Echocardiography, Transesophageal
  • Heart Injuries / etiology
  • Heart Injuries / physiopathology
  • Heart Injuries / surgery
  • Heart Septal Defects, Atrial / diagnostic imaging
  • Heart Septal Defects, Atrial / physiopathology
  • Heart Septal Defects, Atrial / surgery*
  • Humans
  • Iatrogenic Disease*
  • Septal Occluder Device*
  • Treatment Outcome