Innate Immune Cells Speak Manganese

Immunity. 2018 Apr 17;48(4):616-618. doi: 10.1016/j.immuni.2018.03.031.

Abstract

Some metal ions, such as Ca2+ and Zn2+, are involved in intracellular communication in immune cells by acting as second messengers. In this issue of Immunity, Wang et al. (2018) present findings implying a similar role for an additional metal ion, by showing that manganese participates in the recognition of cytoplasmic DNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • DNA
  • DNA Viruses
  • Ions*
  • Manganese*

Substances

  • Ions
  • Manganese
  • DNA