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Review
. 2018 Nov;53(11):1379-1389.
doi: 10.1038/s41409-018-0171-z. Epub 2018 Apr 18.

Epidemiology and biology of relapse after stem cell transplantation

Mary Horowitz  1 , Hans Schreiber  2 , Alex Elder  3 , Olaf Heidenreich  3 , Josef Vormoor  3   4 , Christina Toffalori  5 , Luca Vago  5   6 , Nicolaus Kröger  7
Affiliations
Free PMC article
Review

Epidemiology and biology of relapse after stem cell transplantation

Mary Horowitz et al. Bone Marrow Transplant. 2018 Nov.
Free PMC article
No abstract available

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Conflict of interest statement

None of the authors declared any conflict of interests.

Figures

Figure 1.
Figure 1.
Causes of death among patients transplanted for malignancy in 2012–2013 (Data from the Center for International Blood and Marrow Transplant Research).
Figure 2A-B.
Figure 2A-B.
Five-year outcomes after allogeneic hematopoietic stem cell transplantations for hematologic malignancy by decade (Data from the Center for International Blood and Marrow Transplant Research). (A) Five-year outcomes (in percents) after autologous hematopoietic stem cell transplantations for hematologic malignancy by decade (Data from the Center for International Blood and Marrow Transplant Research). (B)
Figure 2A-B.
Figure 2A-B.
Five-year outcomes after allogeneic hematopoietic stem cell transplantations for hematologic malignancy by decade (Data from the Center for International Blood and Marrow Transplant Research). (A) Five-year outcomes (in percents) after autologous hematopoietic stem cell transplantations for hematologic malignancy by decade (Data from the Center for International Blood and Marrow Transplant Research). (B)
Figure 3A-B.
Figure 3A-B.
Five-year outcomes (in percents) after allogeneic hematopoietic stem cell transplantations for acute myeloid leukemia in first complete remission using myeloablative conditioning in patients aged 20–45 years, by decade (Data from the Center for International Blood and Marrow Transplant Research). (A) Five-year outcomes (in percents) after autologous hematopoietic stem cell transplantations for chemosensitive non-Hodgkin lymphoma in patients aged 20–45 years, by decade (Data from the Center for International Blood and Marrow Transplant Research). (B)
Figure 3A-B.
Figure 3A-B.
Five-year outcomes (in percents) after allogeneic hematopoietic stem cell transplantations for acute myeloid leukemia in first complete remission using myeloablative conditioning in patients aged 20–45 years, by decade (Data from the Center for International Blood and Marrow Transplant Research). (A) Five-year outcomes (in percents) after autologous hematopoietic stem cell transplantations for chemosensitive non-Hodgkin lymphoma in patients aged 20–45 years, by decade (Data from the Center for International Blood and Marrow Transplant Research). (B)
Figure 4.
Figure 4.
Loss of mismatched HLA in leukemic cells after haploidentical HSCT. Schematic model of the causes and consequences of genomic loss of the patient-specific HLA haplotype at relapse after transplantation. Leukemic cells, heterozygous at diagnosis for the shared (in blue) and the mismatched patient-specific (in red) haplotype, are exposed to an intense immunological pressure after transplantation, mostly mediated by donor T cells expressing alloreactive T cell receptors (in green) and targeted against the mismatched HLA haplotype. This selective environment favors the emergence of mutant variants that lack the patient-specific HLA haplotype, and are therefore no longer recognized by donor T lymphocytes.
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