Of mice, men and immunity: a case for evolutionary systems biology

Nat Immunol. 2018 May;19(5):421-425. doi: 10.1038/s41590-018-0084-4.


Animal models have been tremendously useful to translational research, but there is a need to maximize their predictive value to human disease. This Comment proposes novel strategies that consider evolutionary history and the presence, absence or modification of molecular networks in one species that are being studied in the other.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allergy and Immunology*
  • Animals
  • Biological Evolution*
  • Disease Models, Animal*
  • Humans
  • Mice
  • Systems Biology*
  • Translational Medical Research*