Polymorphisms in PARK2 and MRPL37 are associated with higher risk of recurrent venous thromboembolism in a sex-specific manner

J Thromb Thrombolysis. 2018 Aug;46(2):154-165. doi: 10.1007/s11239-018-1662-x.

Abstract

Recent studies indicate that mitochondrial DNA (mtDNA) dysfunction is a biomarker of oxidative stress and can predict the risk of cardiovascular diseases (CVDs). Genetic variants in PARK2 (rs4708928) and MRPL37 (rs10888838) genes have been shown to be associated with altered levels of mtDNA in a sex-specific manner. However, the role of these genetic variants in risk assessment of recurrent venous thromboembolism (VTE) is unknown. We investigated the role of these polymorphisms in VTE recurrence in patients from the Malmö thrombophilia study (MATS, n = 1465), followed for ~ 10 years. Genotyping was performed by TaqMan polymerase chain reaction. Female patients with PARK2 polymorphism had significantly higher risk of VTE recurrence (Hazard ratio [HR] = 2.39, 95% confidence interval [CI] 1.09-5.24) and male patients with MRPL37 polymorphism had a significantly higher risk of VTE recurrence (HR = 1.79, 95% CI 1.01-3.17) on multivariate Cox regression analysis. Combined analysis of these polymorphism with factor V Leiden (FVL) showed that female patients with both, FVL and PARK2 polymorphism had even higher risk of VTE recurrence (HR = 4.49, 95% CI 1.58-12.75) compared to FVL or PARK2 polymorphism alone or both wild-type (reference). Similarly, male patients with both FVL and MRPL37 polymorphism had significantly higher risk of VTE recurrence (HR = 2.97, 95% CI 1.45-6.08) compared to those with FVL or MRPL37 polymorphisms alone or the reference group. Polymorphisms in nuclear genome regulating mtDNA together with FVL may be promising biomarkers for predicting VTE recurrence in a sex specific manner. The abstract should be followed by 3-4 bullet points that highlight the major findings. The final bullet point should address future research.

Keywords: Factor V Leiden; Genetic risk factor; Mitochondria; Predictive biomarkers; Recurrent VTE.

MeSH terms

  • DNA, Mitochondrial / analysis
  • Factor V
  • Female
  • Humans
  • Male
  • Mitochondrial Proteins / genetics*
  • Polymorphism, Genetic
  • Recurrence
  • Ribosomal Proteins / genetics*
  • Risk Assessment
  • Sex Factors
  • Ubiquitin-Protein Ligases / genetics*
  • Venous Thromboembolism / genetics*
  • Venous Thromboembolism / pathology

Substances

  • DNA, Mitochondrial
  • MRPL37 protein, human
  • Mitochondrial Proteins
  • Ribosomal Proteins
  • factor V Leiden
  • Factor V
  • Ubiquitin-Protein Ligases
  • parkin protein