Neural circuits driving larval locomotion in Drosophila

Neural Dev. 2018 Apr 19;13(1):6. doi: 10.1186/s13064-018-0103-z.


More than 30 years of studies into Drosophila melanogaster neurogenesis have revealed fundamental insights into our understanding of axon guidance mechanisms, neural differentiation, and early cell fate decisions. What is less understood is how a group of neurons from disparate anterior-posterior axial positions, lineages and developmental periods of neurogenesis coalesce to form a functional circuit. Using neurogenetic techniques developed in Drosophila it is now possible to study the neural substrates of behavior at single cell resolution. New mapping tools described in this review, allow researchers to chart neural connectivity to better understand how an anatomically simple organism performs complex behaviors.

Keywords: Locomotion; Locomotor circuits; Multisensory integration; Navigation; Neurodevelopment; Sensorimotor; Wave propagation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Drosophila / cytology*
  • Drosophila / physiology*
  • Larva / physiology*
  • Locomotion / physiology*
  • Nerve Net / physiology*