Genetic Dissection of Neural Circuits: A Decade of Progress

Neuron. 2018 Apr 18;98(2):256-281. doi: 10.1016/j.neuron.2018.03.040.


Tremendous progress has been made since Neuron published our Primer on genetic dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical, neurophysiological, and perturbation studies have been carried out in a multitude of invertebrate and vertebrate organisms, linking neurons and circuits to behavioral functions. New methods allow systematic classification of cell types and provide genetic access to diverse neuronal types for studies of connectivity and neural coding during behavior. Here we evaluate key advances over the past decade and discuss future directions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / cytology
  • Brain / metabolism*
  • Brain Chemistry / physiology*
  • Humans
  • Nerve Net / chemistry
  • Nerve Net / cytology
  • Nerve Net / metabolism*
  • Neural Pathways / chemistry
  • Neural Pathways / physiology
  • Neurons / chemistry
  • Neurons / physiology*
  • Optogenetics / methods
  • Optogenetics / trends*
  • Time Factors