Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass

Redox Biol. 2018 Jul:17:47-58. doi: 10.1016/j.redox.2018.04.004. Epub 2018 Apr 6.

Abstract

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Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aging / genetics*
  • Aging / metabolism
  • Aging / pathology
  • Animals
  • Humans
  • Mice
  • Mitochondria / genetics
  • Mitochondria / pathology
  • Muscle Contraction / genetics
  • Muscle Contraction / physiology
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiopathology*
  • NF-E2-Related Factor 2 / deficiency
  • NF-E2-Related Factor 2 / genetics*
  • Oxidation-Reduction
  • Oxidative Stress / genetics*
  • Oxygen Consumption / genetics
  • Reactive Oxygen Species / metabolism

Substances

  • NF-E2-Related Factor 2
  • Nfe2l2 protein, mouse
  • Reactive Oxygen Species