Mirtazapine

Profiles Drug Subst Excip Relat Methodol. 2018:43:209-254. doi: 10.1016/bs.podrm.2018.01.002. Epub 2018 Mar 30.

Abstract

Mirtazapine is one of antidepression which is used mainly in the treatment of depression, moreover, it is sometimes used in the treatment of anxiety disorders, insomnia, nausea, and vomiting, and to produce weight gain when desirable. The action of mirtazapine is an antagonist of certain adrenergic and serotonin receptors, and, furthermore, the drug is used strong as antihistamine, and it is occasionally defined as a noradrenergic and specific serotonergic antidepressant (NaSSA). The comprehensive profile of mirtazapine gives more detailed information about nomenclature, formulae, elemental analysis, and appearance. In addition, the numerous methods of drug synthesis are summarized. Also the profile covers the physicochemical properties as: the value of pKa, drug solubility, melting point, X-ray powder diffraction, and analysis methods for example: (compendial, electrochemical, spectroscopic, and method of chromatographic). Besides that, the profile covered pharmacological profile and clinical pharmacokinetics in subtitle's (absorption, distribution, metabolism, and elimination). About 100 references were given as a proof of the above-mentioned studies.

Keywords: Clinical pharmacokinetics; Method of analysis; Mirtazapine; Nomenclature; Pharmacological profile; Physical characteristics; Spectroscopy; Stability; Synthesis.

Publication types

  • Review

MeSH terms

  • Adrenergic alpha-Antagonists / chemistry*
  • Adrenergic alpha-Antagonists / pharmacokinetics
  • Animals
  • Antidepressive Agents, Tricyclic / chemistry*
  • Antidepressive Agents, Tricyclic / pharmacokinetics
  • Biological Availability
  • Biotransformation
  • Drug Compounding
  • Drug Stability
  • Humans
  • Mianserin / analogs & derivatives*
  • Mianserin / chemistry
  • Mianserin / pharmacokinetics
  • Mirtazapine
  • Serotonin Antagonists / chemistry*
  • Serotonin Antagonists / pharmacokinetics
  • Technology, Pharmaceutical / methods

Substances

  • Adrenergic alpha-Antagonists
  • Antidepressive Agents, Tricyclic
  • Serotonin Antagonists
  • Mianserin
  • Mirtazapine