Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy

J Steroid Biochem Mol Biol. 2018 Sep:182:27-36. doi: 10.1016/j.jsbmb.2018.04.008. Epub 2018 Apr 17.


Polycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of reproductive age. This syndrome leads to infertility, insulin resistance, obesity, and cardiovascular problems, including a litany of other health issues. PCOS is a polygenic, polyfactorial, systemic, inflammatory, dysregulated steroid state, autoimmune disease, manifesting largely due to lifestyle errors. The advent of biochemical tests and ultrasound scanning has enabled the detection of PCOS in the affected females. Subsequently, a huge amount of insight on PCOS has been garnered in recent times. Interventions like oral contraceptive pills, metformin, and hormone therapy have been developed to bypass or reverse the ill effects of PCOS. However, lifestyle correction to prevent aberrant immune activation and to minimize the exposure to inflammatory agents, appears to be the sustainable therapy of PCOS. This holistic review with multiple hypotheses might facilitate to devise better PCOS management approaches.

Keywords: Amenorrhea; Anovulation; Endocrine disorder; Hyperandrogenism; Hyperprolactinemia; Polycystic ovary syndrome (PCOS).

Publication types

  • Review

MeSH terms

  • Endocrine System / physiopathology*
  • Female
  • Humans
  • Inflammation / complications*
  • Insulin Resistance*
  • Life Style*
  • Obesity / complications*
  • Polycystic Ovary Syndrome / etiology*
  • Polycystic Ovary Syndrome / pathology