Thyroid hormone actions on male reproductive system of teleost fish

Gen Comp Endocrinol. 2018 Sep 1;265:230-236. doi: 10.1016/j.ygcen.2018.04.023. Epub 2018 Apr 17.

Abstract

Thyroid hormones (THs) play important roles in the regulation of many biological processes of vertebrates, such as growth, metabolism, morphogenesis and reproduction. An increasing number of studies have been focused on the involvement of THs in the male reproductive system of vertebrates, in particular of fish. Therefore, this mini-review aims to summarize the main findings on THs role in male reproductive system of fish, focusing on sex differentiation, testicular development and spermatogenesis. The existing data in the literature have demonstrated that THs exert their roles at the different levels of the hypothalamic-pituitary-gonadal (HPG) axis. In general a positive correlation has been shown between THs and fish reproductive status; where THs are associated with testicular development, growth and maturation. Recently, the molecular mechanisms underlying the role of THs in spermatogenesis have been unraveled in zebrafish testis. THs promote germ cell proliferation and differentiation by increasing a stimulatory growth factor of spermatogenesis produced by Sertoli cells. In addition, THs enhanced the gonadotropin-induced androgen release in zebrafish testis. Next to their functions in the adult testis, THs are involved in the gonadal sex differentiation through modulating sex-related gene expression, and testicular development via regulation of Sertoli cell proliferation. In conclusion, this mini-review showed that THs modulate the male reproductive system during the different life stages of fish. The physiological and molecular mechanisms showed a link between the thyroid and reproduction, suggesting a possibly co-evolution and interdependence of these two systems.

Keywords: Adult testis; Reproduction; Sex differentiation; Spermatogenesis; Teleost fish; Testicular development; Thyroid hormones.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Fishes / physiology*
  • Male
  • Reproduction / drug effects
  • Reproduction / physiology*
  • Sex Differentiation / drug effects
  • Sex Differentiation / physiology
  • Testis / drug effects*
  • Testis / embryology
  • Testis / metabolism
  • Thyroid Gland / drug effects
  • Thyroid Gland / metabolism
  • Thyroid Hormones / pharmacology*

Substances

  • Thyroid Hormones