The Effect of Hyperbaric Oxygen Therapy on Myocardial Perfusion after the Implantation of Drug-Eluting Stents

Ann Clin Lab Sci. 2018 Mar;48(2):158-163.


Aim: The study is to investigate hyperbaric oxygen therapy (HBOT) on myocardial perfusion of patients after the implantation of drug-eluting stents (DES) METHODS: From December 2013 to December 2015, a total of 115 patients with CAD who received DES implantation were included in this retrospective study. They were divided into HBOT group (n=55) and control group (n=60) according to different treatments retrospectively. Gated myocardial perfusion single photon emission computed tomography (SPECT) was conducted in all the patients. Endothelin-1 (ET-1), high sensitivity C reactive protein (hs-CRP) and nitric oxide (NO) were detected by the corresponding assay kits.

Results: After HBOT treatment in HBOT group, SPECT results showed that the improvement rate of impaired sub-segments in patients of HBOT was significantly higher than that in control group (P<0.05), and the parameters of PFR, TPFR, MFR/3 were displayed with marked differences between the two groups (P<0.05). The laboratory results demonstrated a statistically increased level of NO and decreased levels of ET-1 and hs-CRP between the two groups (P<0.05).

Conclusions: HBO may improve myocardial blood perfusion, reduce inflammation and vascular endothelial dysfunction, and further improve myocardial microcirculation in patients after the implantation of drug-eluting stents.

MeSH terms

  • Adult
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Anticoagulants / therapeutic use
  • Blood Pressure / physiology
  • C-Reactive Protein / metabolism
  • Coronary Artery Disease / diagnostic imaging*
  • Coronary Artery Disease / therapy*
  • Drug-Eluting Stents*
  • Endothelin-1 / metabolism
  • Female
  • Heart Rate / physiology
  • Humans
  • Hyperbaric Oxygenation / methods*
  • Male
  • Middle Aged
  • Myocardial Perfusion Imaging*
  • Retrospective Studies
  • Tomography, Emission-Computed, Single-Photon


  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticoagulants
  • Endothelin-1
  • C-Reactive Protein