The role of adult hippocampal neurogenesis in brain health and disease

Mol Psychiatry. 2019 Jan;24(1):67-87. doi: 10.1038/s41380-018-0036-2. Epub 2018 Apr 20.


Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encoding and mood regulation. In addition, several brain diseases, such as neurological diseases and mood disorders, have deleterious effects on adult hippocampal neurogenesis, and some symptoms of those diseases can be partially explained by the dysregulation of adult hippocampal neurogenesis. Here we review a possible link between the physiological functions of adult-born neurons and their roles in pathological conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Affect / physiology
  • Brain / pathology
  • Brain / physiology
  • Brain Diseases / pathology
  • Dentate Gyrus / pathology
  • Dentate Gyrus / physiology
  • Hippocampus / metabolism
  • Hippocampus / pathology*
  • Hippocampus / physiology*
  • Humans
  • Memory / physiology
  • Neurogenesis / physiology*
  • Neuronal Plasticity / physiology
  • Neurons / physiology
  • Temporal Lobe / pathology