Effects of different natural extracts in an experimental model of benign prostatic hyperplasia (BPH)

Inflamm Res. 2018 Jul;67(7):617-626. doi: 10.1007/s00011-018-1152-9. Epub 2018 Apr 20.


Objective and design: To characterize the impact of inflammatory process and oxidative stress in the degree of benign prostatic hyperplasia (BPH), a common condition in which chronic inflammation plays a crucial role, we investigated the effect of different plant extract preparations in an in vivo model of BPH as new therapeutic target.

Material: BPH was made in rats with daily administration of testosterone propionate (3 mg/kg) for 14 days.

Treatment: Rats were randomized into different groups to receive oral administration of plant extract preparations: Serenoa repens with selenium (SeR 28.5 mg/kg associated with Se 0.005 mg/kg), Teoside (2 mg/kg), and Puryprost (14 mg/kg containing Teoside 50% 2 mg/kg and Epilobium 12 mg/kg).

Methods: After 14 days, rats were killed and histological changes, prostate weight and apoptotic pathways were assayed.

Results: The results obtained demonstrated that the association of treatments reduced prostate weight and hyperplasia, while treatment with Puryprost demonstrated a greater trend of protection compared to the other treatments.

Conclusion: Thus, our results indicate that plant extract could be considered as new useful therapy in the treatment of BPH with particular attention on Puryprost that represents a rational approach to reduce BPH through modulation of inflammatory process and anti-oxidant process.

Keywords: Benign prostatic hyperplasia; Inflammation; Natural extract; Oxidative stress.

MeSH terms

  • Ajuga*
  • Animals
  • Apoptosis / drug effects
  • Cholestenone 5 alpha-Reductase / metabolism
  • Cyclooxygenase 2 / metabolism
  • Dihydrotestosterone / blood
  • Dinoprostone / metabolism
  • Disease Models, Animal
  • Epilobium*
  • Male
  • Malondialdehyde / metabolism
  • NF-KappaB Inhibitor alpha / metabolism
  • NF-kappa B / metabolism
  • Nitric Oxide Synthase Type II / metabolism
  • Phytotherapy
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Prostate / drug effects
  • Prostate / metabolism
  • Prostate / pathology
  • Prostatic Hyperplasia / chemically induced
  • Prostatic Hyperplasia / drug therapy*
  • Prostatic Hyperplasia / pathology
  • Rats, Sprague-Dawley
  • Selenium / pharmacology
  • Selenium / therapeutic use*
  • Serenoa*
  • Testosterone Propionate


  • NF-kappa B
  • Plant Extracts
  • Dihydrotestosterone
  • NF-KappaB Inhibitor alpha
  • Malondialdehyde
  • Nitric Oxide Synthase Type II
  • Nos2 protein, rat
  • Cyclooxygenase 2
  • Ptgs2 protein, rat
  • Cholestenone 5 alpha-Reductase
  • Selenium
  • Dinoprostone
  • Testosterone Propionate