Bat-Origin Coronaviruses Expand Their Host Range to Pigs

Liang Wang; Shuo Su; Yuhai Bi; Gary Wong; George F Gao

doi:10.1016/j.tim.2018.03.001

Bat-Origin Coronaviruses Expand Their Host Range to Pigs

Trends Microbiol. 2018 Jun;26(6):466-470. doi: 10.1016/j.tim.2018.03.001. Epub 2018 Apr 18.

Authors

Liang Wang¹, Shuo Su², Yuhai Bi³, Gary Wong⁴, George F Gao⁵

Affiliations

¹ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China.
² MOE Joint International Research Laboratory of Animal Health and Food Safety, Jiangsu Engineering Laboratory of Animal Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
³ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China; Shenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen 518112, China.
⁴ Shenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen 518112, China.
⁵ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China; Shenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen 518112, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China. Electronic address: gaof@im.ac.cn.

Abstract

Infections with bat-origin coronaviruses have caused severe illness in humans by 'host jump'. Recently, novel bat-origin coronaviruses were found in pigs. The large number of mutations on the receptor-binding domain allowed the viruses to infect the new host, posing a potential threat to both agriculture and public health.

Keywords: SeACoV; bat-origin; host jump; public health; swine enteric alphacoronaviruses.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alphacoronavirus / genetics
Animals
Animals, Wild / virology
China / epidemiology
Chiroptera / virology*
Coronavirus Infections / epidemiology
Coronavirus Infections / transmission
Coronavirus Infections / veterinary*
Genetic Variation
Host Specificity*
Humans
Phylogeny
Swine / virology*