Bat-Origin Coronaviruses Expand Their Host Range to Pigs

Trends Microbiol. 2018 Jun;26(6):466-470. doi: 10.1016/j.tim.2018.03.001. Epub 2018 Apr 18.


Infections with bat-origin coronaviruses have caused severe illness in humans by 'host jump'. Recently, novel bat-origin coronaviruses were found in pigs. The large number of mutations on the receptor-binding domain allowed the viruses to infect the new host, posing a potential threat to both agriculture and public health.

Keywords: SeACoV; bat-origin; host jump; public health; swine enteric alphacoronaviruses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alphacoronavirus / genetics
  • Animals
  • Animals, Wild / virology
  • China / epidemiology
  • Chiroptera / virology*
  • Coronavirus Infections / epidemiology
  • Coronavirus Infections / transmission
  • Coronavirus Infections / veterinary*
  • Genetic Variation
  • Host Specificity*
  • Humans
  • Phylogeny
  • Swine / virology*