Effect of kibble and raw meat diets on peripheral blood mononuclear cell gene expression profile in dogs

R C Anderson; K M Armstrong; W Young; P Maclean; D G Thomas; E N Bermingham

doi:10.1016/j.tvjl.2018.01.005

Effect of kibble and raw meat diets on peripheral blood mononuclear cell gene expression profile in dogs

Vet J. 2018 Apr:234:7-10. doi: 10.1016/j.tvjl.2018.01.005. Epub 2018 Feb 7.

Authors

R C Anderson¹, K M Armstrong², W Young¹, P Maclean³, D G Thomas⁴, E N Bermingham⁵

Affiliations

¹ Food Nutrition and Health Team, AgResearch, Palmerston North, New Zealand; Riddet Institute, Massey University, Palmerston North, New Zealand.
² Food Nutrition and Health Team, AgResearch, Palmerston North, New Zealand.
³ Bioinformatics and Statistics Team, AgResearch, Lincoln, New Zealand.
⁴ Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
⁵ Food Nutrition and Health Team, AgResearch, Palmerston North, New Zealand. Electronic address: emma.bermingham@agresearch.co.nz.

PMID: 29680397
DOI: 10.1016/j.tvjl.2018.01.005

Abstract

Peripheral blood mononuclear cell (PBMC) gene expression microarray profiling is a minimally invasive tool used in human diet intervention studies. In this study, PBMC gene expression was determined in dogs fed kibble or raw red meat diets for 9 weeks to test the hypothesis that diet influences canine immune cell gene expression profiles. The two diets were associated with differences in PBMC gene expression profiles, which corresponded with changes in plasma IgA concentrations. Analysis of PBMC gene expression profiles might provide useful insights into the long term effects of diet on health outcomes in dogs.

Keywords: Biomarkers; Canine; Diet; Immune status; Microarray gene expression analysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animal Feed / standards
Animals
Diet* / veterinary
Dogs / blood*
Gene Expression Profiling*
Humans
Leukocytes, Mononuclear / metabolism*
Meat
Transcriptome