The role of CKIP-1 in osteoporosis development and treatment

X Peng; X Wu; J Zhang; G Zhang; G Li; X Pan

doi:10.1302/2046-3758.72.BJR-2017-0172.R1

The role of CKIP-1 in osteoporosis development and treatment

Bone Joint Res. 2018 Apr 12;7(2):173-178. doi: 10.1302/2046-3758.72.BJR-2017-0172.R1. eCollection 2018 Feb.

Authors

X Peng¹, X Wu¹, J Zhang², G Zhang³, G Li², X Pan¹

Affiliations

¹ Department of Orthopaedics and Traumatology, People's Hospital of Bao'an District, Affiliated to Southern Medical University, and Affiliated to Guangdong Medical University, Longjing 2nd Rd, Bao'an District, Shenzhen, China.
² Department of Orthopaedics and Traumatology, Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China.
³ Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Baptist University Road, Kowloon Tong, Hong Kong, China.

PMID: 29682283
PMCID: PMC5895943
DOI: 10.1302/2046-3758.72.BJR-2017-0172.R1

Abstract

Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment. Cite this article: X. Peng, X. Wu, J. Zhang, G. Zhang, G. Li, X. Pan. The role of CKIP-1 in osteoporosis development and treatment. Bone Joint Res 2018;7:173-178. DOI: 10.1302/2046-3758.72.BJR-2017-0172.R1.

Keywords: BMP pathway; Bone formation; CKIP-1; Osteoporosis.