Let's fight cancer: let-7 is a tool to enhance antitumor immune responses

Future Oncol. 2018 May;14(12):1141-1145. doi: 10.2217/fon-2018-0037. Epub 2018 Apr 23.

Authors

Leonid A Pobezinsky¹, Alexandria C Wells¹

Affiliation

¹ Department of Veterinary & Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA.

PMID: 29683340
DOI: 10.2217/fon-2018-0037

No abstract available

Keywords: CD8 T cells; CTLs; RNAi; cancer; cytotoxic response; eomes; let-7; miRNA; tumor; vaccines/immunotherapy.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / pharmacology*
Antineoplastic Agents / therapeutic use
Cancer Vaccines / immunology
Cancer Vaccines / therapeutic use
Costimulatory and Inhibitory T-Cell Receptors / antagonists & inhibitors
Costimulatory and Inhibitory T-Cell Receptors / immunology
Dendritic Cells / immunology
Dendritic Cells / metabolism
Gene Expression Regulation, Neoplastic / immunology*
Humans
Immunotherapy / methods*
MicroRNAs / antagonists & inhibitors
MicroRNAs / immunology
MicroRNAs / metabolism*
Neoplasms / genetics
Neoplasms / immunology
T-Lymphocytes, Cytotoxic / immunology
T-Lymphocytes, Cytotoxic / metabolism
Treatment Outcome
Tumor Microenvironment / genetics
Tumor Microenvironment / immunology

Substances

Antineoplastic Agents
Cancer Vaccines
Costimulatory and Inhibitory T-Cell Receptors
MicroRNAs
mirnlet7 microRNA, human