225 intracranial aneurysms treated with the Low-profile Visualized Intraluminal Support (LVIS) stent: a single-center retrospective study

Neurol Res. 2018 Jun;40(6):445-451. doi: 10.1080/01616412.2018.1457608. Epub 2018 Apr 23.


Background For the treatment of intracranial aneurysms, the low-profile visualized intraluminal support (LVIS) stent is a new generation of highly visible-braided stent that was recently introduced in China. Here, we report our single-center retrospective experience of safety and efficacy utilizing LVIS for stent-assisted coiling of intracranial aneurysms. Methods We included 218 patients with intracranial aneurysms consecutively treated with LVIS SR stents at our center in this study. Postoperative and follow-up embolization scores, procedural complications, clinical and angiographic findings at mid-term follow-up, as well as recurrence rate, preoperative and follow-up mRS scores were analyzed. Results Two hundred and eighteen patients with two hundred and twenty five intracranial aneurysms were enrolled. The locations and distribution were ICA (125, 55.6%), PcomA (47, 20.9%), VA (38, 16.8%), and BA (15, 6.7%). Two hundred and eighteen aneurysms were treated with the stent-assisted coiling and seven patients with LVIS stents alone. Angiographic follow-up was available for 115 (51.1%) aneurysms, 8 (7.0%) of which had recurrences including 7 (6.5%) unruptured aneurysms and 1(14.3%) ruptured aneurysm. The procedural complication rate was 2.75% in total, including distal hemorrhage (1, 0.45%; SAH), ischemic events (5, 2.3%). Conclusions Our single-center retrospective experience is one of the larger studies to date assessing the LVIS device. Compared with many laser-cut stent studies, the LVIS device had a higher aneurysm complete occlusion rate at follow-up coupled with low complication rates. However, this study was our initial experience with LVIS, larger patient numbers, and longer follow-up will be needed to fully assess the long-term efficacy of LVIS in treating intracranial aneurysms.

Keywords: AA: arachidonic acid; ADP: adenosine diphosphate; CTA: computed tomography angiography; DM: diabetes mellitus; DSA: digital subtract angiography; HBP: high blood pressure; IAs: intracranial aneurysms; Intracranial aneurysm; MRA: magnetic resonance angiography; SAH: subarachnoid hemorrhage; SD: standard deviation; Thromboembolism; low-profile stent; mRS: modified Rankin Scale; stent-assisted coil.

MeSH terms

  • Anticoagulants / therapeutic use
  • Cerebral Angiography
  • Endovascular Procedures
  • Female
  • Follow-Up Studies
  • Humans
  • Intracranial Aneurysm / diagnostic imaging
  • Intracranial Aneurysm / drug therapy
  • Intracranial Aneurysm / surgery*
  • Male
  • Middle Aged
  • Platelet Aggregation Inhibitors / therapeutic use
  • Postoperative Complications
  • Recurrence
  • Retrospective Studies
  • Stents*


  • Anticoagulants
  • Platelet Aggregation Inhibitors