Relation of intrathecal oligoclonal band production to inflammatory mediator and immunotherapy response in 208 children with OMS

J Neuroimmunol. 2018 Aug 15:321:150-156. doi: 10.1016/j.jneuroim.2018.04.007. Epub 2018 Apr 12.

Abstract

In 208 children with opsoclonus-myoclonus syndrome (OMS), CSF IgG oligoclonal bands (OCB) and 22 immunomarkers in CSF and 21 in serum/blood were measured. In 36 untreated OMS, 58% were OCB(+), whereas 55% of treated OMS were OCB(-). OCB positivity or negativity did not alter concentrations or frequencies of immunomarkers. The phenotypes of OCB(+) and OCB(-) patients were not distinctive. CSF B cells were expanded in untreated OMS regardless of OCB positivity. These data reveal a much higher frequency of OCB positivity in untreated OMS than previously realized and a disconnect between intrathecal OCB and inflammatory mediator production.

Keywords: CSF B cells; CSF chemokines; Neuroblastoma; Neuroinflammation; Opsoclonus-myoclonus syndrome; Paraneoplastic disorders; Pediatric neuroinflammatory disorders.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood
  • Biomarkers / cerebrospinal fluid
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Humans
  • Immunologic Factors / blood
  • Immunologic Factors / cerebrospinal fluid
  • Immunotherapy / methods*
  • Inflammation Mediators / blood*
  • Inflammation Mediators / cerebrospinal fluid*
  • Male
  • Oligoclonal Bands / blood*
  • Oligoclonal Bands / cerebrospinal fluid*
  • Opsoclonus-Myoclonus Syndrome / blood*
  • Opsoclonus-Myoclonus Syndrome / cerebrospinal fluid*
  • Opsoclonus-Myoclonus Syndrome / drug therapy
  • Retrospective Studies
  • Treatment Outcome

Substances

  • Biomarkers
  • Immunologic Factors
  • Inflammation Mediators
  • Oligoclonal Bands