Autonomic nervous system network and liver regeneration

World J Gastroenterol. 2018 Apr 21;24(15):1616-1621. doi: 10.3748/wjg.v24.i15.1616.


To date, various signal transducers, cytokines, growth factors, and hormones have been reported to play an important role in homeostasis of various organs. Various cells and organs are involved in the hepatic regeneration process, which proceeds as a result of the coordination of many factors. While these factors are well known to be involved in the liver regeneration after the liver injury, however, as the details of such mechanisms have not been sufficiently elucidated, the practical applicability of hepatic regeneration based on the action of these and cytokines growth factors is still unclear. In terms of the involvement of the autonomic nervous system in hepatic regeneration, cell proliferation resulting from direct signal transduction to the liver has also been reported and recent studies focusing on the inter-organ communication via neural network opened a novel aspect of this field for therapeutic applicability. Therefore, the appropriate understanding of the relationship between autonomic neural network and liver regeneration through various organs including brain, afferent nerve, efferent nerve, etc. is essential. This mini-review explains the principle of neural system involved in the inter-organ communication and its contribution on the liver regeneration upon the liver injury reviewing recent progress in this field.

Keywords: Autonomic nerve; Hormone; Liver regeneration; Neural network.

Publication types

  • Review

MeSH terms

  • Afferent Pathways / physiology
  • Animals
  • Autonomic Nervous System / physiology*
  • Brain / physiology
  • Cell Proliferation / physiology
  • Cytokines / metabolism
  • Efferent Pathways / physiology
  • Humans
  • Liver / innervation*
  • Liver / physiology
  • Liver Regeneration / physiology*
  • Serotonin / metabolism
  • Signal Transduction / physiology*


  • Cytokines
  • Serotonin