Dehydroepiandrosterone sulfate improves memory in aging mice

Brain Res. 1988 May 10;448(1):178-81. doi: 10.1016/0006-8993(88)91116-x.


Middle-aged (18 month old) and old (24 month old) mice showed poorer retention of footshock active avoidance training (FAAT) than young mice (2 month old). Immediate post-training subcutaneous injection of dehydroepiandrosterone sulfate (DHEAS) improved retention of FAAT in middle-aged and old mice to the high levels observed in young mice. DHEAS, a major naturally occurring adrenal steroid that decreases in blood serum with age, could be rate-limiting in achievement of retention of learning.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging
  • Animals
  • Avoidance Learning / drug effects
  • Dehydroepiandrosterone / analogs & derivatives*
  • Dehydroepiandrosterone / pharmacology
  • Dehydroepiandrosterone Sulfate
  • Male
  • Memory / drug effects*
  • Mice
  • Mice, Inbred C57BL


  • Dehydroepiandrosterone
  • Dehydroepiandrosterone Sulfate