Myonuclear Positioning and Aneurysms Are LINC'd by Ariande

Mridula Balakrishnan; Mary K Baylies

doi:10.1016/j.devcel.2018.04.004

Myonuclear Positioning and Aneurysms Are LINC'd by Ariande

Dev Cell. 2018 Apr 23;45(2):149-150. doi: 10.1016/j.devcel.2018.04.004.

Authors

Mridula Balakrishnan¹, Mary K Baylies²

Affiliations

¹ Program in Biochemistry, Cell and Molecular Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
² Program in Biochemistry, Cell and Molecular Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: m-baylies@ski.mskcc.org.

Abstract

In this issue of Developmental Cell, Tan et al. (2018) show how a novel player in myonuclear positioning, the ubiquitin ligase Ari-1, regulates levels of Koi, a member of the LINC mechanosensing complex, and affects nuclear morphology and positioning in both Drosophila muscles and human vascular smooth muscle cells.

Publication types

Comment

MeSH terms

Aneurysm
Animals
Cell Nucleus*
Drosophila
Humans
Muscles
Nuclear Envelope*

Abstract

Publication types

MeSH terms

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