Myonuclear Positioning and Aneurysms Are LINC'd by Ariande

Dev Cell. 2018 Apr 23;45(2):149-150. doi: 10.1016/j.devcel.2018.04.004.


In this issue of Developmental Cell, Tan et al. (2018) show how a novel player in myonuclear positioning, the ubiquitin ligase Ari-1, regulates levels of Koi, a member of the LINC mechanosensing complex, and affects nuclear morphology and positioning in both Drosophila muscles and human vascular smooth muscle cells.

Publication types

  • Comment

MeSH terms

  • Aneurysm
  • Animals
  • Cell Nucleus*
  • Drosophila
  • Humans
  • Muscles
  • Nuclear Envelope*