Acidic fibroblast growth factor stimulates opsin levels in retinal photoreceptor cells in vitro

FEBS Lett. 1988 Jul 18;234(2):475-9. doi: 10.1016/0014-5793(88)80141-8.

Abstract

It is demonstrated that newborn rat retinal photoreceptor cells can differentiate in monolayer culture, and synthesize de novo photoreceptor-specific proteins such as opsin. When maintained in serum supplemented medium on a laminin substrate, these cells survive for up to 3 weeks. The addition of acidic fibroblast growth factor stimulates an increase in the levels of opsin of 5-10-fold control values, and prolongs cell survival by up to 6 days.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Eye Proteins / metabolism*
  • Fibroblast Growth Factors / pharmacology*
  • Kinetics
  • Photoreceptor Cells / drug effects
  • Photoreceptor Cells / metabolism*
  • Radioimmunoassay
  • Rats
  • Retinal Pigments / metabolism*
  • Rod Opsins

Substances

  • Eye Proteins
  • Retinal Pigments
  • Rod Opsins
  • Fibroblast Growth Factors