Joint regression and classification via relational regularization for Parkinson's disease diagnosis

Technol Health Care. 2018;26(S1):19-30. doi: 10.3233/THC-174540.


It is known that the symptoms of Parkinson's disease (PD) progress successively, early and accurate diagnosis of the disease is of great importance, which slows the disease deterioration further and alleviates mental and physical suffering. In this paper, we propose a joint regression and classification scheme for PD diagnosis using baseline multi-modal neuroimaging data. Specifically, we devise a new feature selection method via relational learning in a unified multi-task feature selection model. Three kinds of relationships (e.g., relationships among features, responses, and subjects) are integrated to represent the similarities among features, responses, and subjects. Our proposed method exploits five regression variables (depression, sleep, olfaction, cognition scores and a clinical label) to jointly select the most discriminative features for clinical scores prediction and class label identification. Extensive experiments are conducted to demonstrate the effectiveness of the proposed method on the Parkinson's Progression Markers Initiative (PPMI) dataset. Our experimental results demonstrate that multi-modal data can effectively enhance the performance in class label identification compared with single modal data. Our proposed method can greatly improve the performance in clinical scores prediction and outperforms the state-of-art methods as well. The identified brain regions can be recognized for further medical analysis and diagnosis.

Keywords: Parkinson’s disease; classification; feature selection; multi-modality; score prediction.

MeSH terms

  • Aged
  • Disease Progression*
  • Female
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Joints / diagnostic imaging*
  • Male
  • Middle Aged
  • Neuroimaging / methods*
  • Parkinson Disease / diagnosis*
  • Pattern Recognition, Automated / methods*
  • Positron-Emission Tomography / methods*