Renal hypertrophy in experimental diabetes: some functional aspects

J Diabet Complications. Jan-Mar 1987;1(1):7-10. doi: 10.1016/s0891-6632(87)80018-1.


Glomerular filtration rate (GFR) was measured by constant infusion of iothalamate in conscious rats with and without streptozotocin diabetes. Kidney weight had already increased significantly after 4 days of diabetes. GFR was unchanged at that time, but increased subsequently, so that GFR/kidney weight was normal after 1 month of diabetes. Tubular glucose reabsorption rate was increased to the same extent as kidney weight after 4 days of diabetes. It is concluded that renal growth in experimental diabetes cannot be initiated by glomerular hyperfiltration, but that increased glucose reabsorption may have a causal role.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Diabetes Mellitus, Experimental / physiopathology*
  • Female
  • Glomerular Filtration Rate
  • Glucose / metabolism
  • Hypertrophy
  • Iothalamic Acid
  • Kidney / pathology
  • Kidney / physiopathology*
  • Kidney Tubules, Proximal / physiopathology
  • Rats
  • Rats, Inbred Strains
  • Time Factors


  • Iothalamic Acid
  • Glucose