Evaluation of magnetic nanoparticles influence on hyaluronic acid production from Streptococcus equi

Yasser A Attia; Mohamed I Kobeasy; Mohamed Samer

doi:10.1016/j.carbpol.2018.03.037

Evaluation of magnetic nanoparticles influence on hyaluronic acid production from Streptococcus equi

Carbohydr Polym. 2018 Jul 15:192:135-142. doi: 10.1016/j.carbpol.2018.03.037. Epub 2018 Mar 19.

Authors

Yasser A Attia¹, Mohamed I Kobeasy², Mohamed Samer³

Affiliations

¹ National Institute of Laser Enhanced Sciences, Cairo University, 12613 Giza, Egypt. Electronic address: yasserniles@niles.edu.eg.
² Department of Biochemistry, Faculty of Agriculture, Cairo University, 12613 Giza, Egypt; Faculty of Science, Department of Chemistry, Taif University, Taif 21974, Saudi Arabia. Electronic address: m.kobeasy@tu.edu.sa.
³ Department of Agricultural Engineering, Faculty of Agriculture, Cairo University, 12613 Giza, Egypt. Electronic address: msamer@agr.cu.edu.eg.

PMID: 29691005
DOI: 10.1016/j.carbpol.2018.03.037

Abstract

This work aims at developing a novel hyaluronic acid (HA) production method using magnetic nanoparticles (NPs). In a separate process, HA was produced with the addition of the amino acids (AA) as bio-additives. Regarding the NPs additives, the results showed that the highest dry weight of the produced HA was 0.264 g/l with the addition of 20 mg/l of Fe₃O₄ NPs. Concerning the AA additives, the results showed that the highest dry weight of the produced HA was 0.079 g/l with the addition of 0.26 g/l of glutamic acid (GA) compared to the control produced 0.065 g/l. These results led to further develop a novel HA production method which is preparing the Fe₃O₄ NPs using GA as stabilizer, where the results showed that dry weight of the produced HA was 0.435 g/l with the addition of 20 mg/l of Fe₃O₄-GA NPs.

Keywords: Biomaterials; Hyaluronic acid; Mutants; Nanomaterials; Nanoparticles; Pharmaceuticals.