Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemotherapy (HIPEC) by Minimally Invasive Approach, an Initial Experience

World J Surg. 2018 Oct;42(10):3120-3124. doi: 10.1007/s00268-018-4634-6.


Background: The cytoreductive surgery (CRS) associated with hyperthermic intraperitoneal chemotherapy (HIPEC) has become the standard treatment in patients with carcinomatosis peritoneal from different origins. The use of a minimally invasive approach for this high complex procedure might be an alternative that provides them less morbidity and faster recovery with similar oncologic outcomes.

Methods: We describe the initial experience of CRS and HIPEC done via the laparoscopic route in patients with minimal peritoneal metastases in our Unit from March 2016 to January 2018.

Results: A total of eight patients were operated by this minimally invasive approach. The different diagnoses were low-grade pseudomyxoma peritonei (2), benign multicystic mesothelioma (2), primary epithelial ovarian carcinomatosis (2) and locally advanced colon carcinoma T4 (2). The median age was 54 (20-62) years, the median PCI was 3 (2-4), the median operative time was 287 min (240-360), complete cytoreduction CC0 was achieved in all the patients, and no major morbidity was observed. The median length of stay was 4.75 days (4-5). After a median follow-up of 9.5 months, no relapse has been observed.

Conclusion: The results suggest that this minimally invasive approach for CRS and HIPEC is feasible and safe in a highly selected group of patients with peritoneal surface malignancies.

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Carcinoma / surgery
  • Colonic Neoplasms / drug therapy
  • Colonic Neoplasms / surgery
  • Cytoreduction Surgical Procedures*
  • Female
  • Humans
  • Hyperthermia, Induced*
  • Laparoscopy
  • Male
  • Mesothelioma / drug therapy
  • Mesothelioma / surgery
  • Middle Aged
  • Neoplasm Recurrence, Local / surgery
  • Ovarian Neoplasms / drug therapy
  • Ovarian Neoplasms / surgery
  • Percutaneous Coronary Intervention
  • Peritoneal Neoplasms / secondary
  • Peritoneal Neoplasms / surgery*
  • Peritoneum
  • Prospective Studies
  • Pseudomyxoma Peritonei / drug therapy*
  • Pseudomyxoma Peritonei / surgery
  • Retrospective Studies
  • Young Adult