Fighting against Skin Aging: The Way from Bench to Bedside

Cell Transplant. 2018 May;27(5):729-738. doi: 10.1177/0963689717725755. Epub 2018 Apr 25.


As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. In this review, we summarize these changes in skin aging, research advances of the molecular mechanisms leading to these changes, and the treatment strategies aimed at preventing or reversing skin aging.

Keywords: extracellular matrix; extrinsic aging; intrinsic aging; skin aging; treatment strategy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Inflammation / pathology
  • Models, Biological
  • Skin Aging / genetics
  • Skin Aging / physiology*
  • Stem Cell Transplantation
  • Telomere / metabolism
  • Translational Research, Biomedical*