Despite effective treatment, HIV can persist in latent reservoirs, which represent a major obstacle toward HIV eradication. Targeting and reactivating latent cells is challenging due to the heterogeneous nature of HIV-infected cells. Here, we used a primary model of HIV latency and single-cell RNA sequencing to characterize transcriptional heterogeneity during HIV latency and reactivation. Our analysis identified transcriptional programs leading to successful reactivation of HIV expression.
Keywords: HIV; cure; heterogeneity; inducible cell; latency; reactivation; scRNA-seq; signature; single cell; transcriptome.
Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.