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, 52 (11-12), 1328-1335

Carbon Monoxide Ameliorates Murine T-cell-dependent Colitis Through the Inhibition of Th17 Differentiation

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Carbon Monoxide Ameliorates Murine T-cell-dependent Colitis Through the Inhibition of Th17 Differentiation

Tomohisa Takagi et al. Free Radic Res.

Abstract

Recent studies have identified carbon monoxide (CO) as a potential therapeutic molecule for the treatment of inflammatory diseases including intestinal inflammation. In the present study, we explored the efficacy and the mechanisms of action of CO-releasing molecule (CORM)-A1 in T-cell transfer induced colitis model in mice. In addition, the impact of CORM-A1 on the T helper (Th) cell differentiation was evaluated using naïve CD4+ T cells isolated from the spleens in Balb/c mice. The results showed that CORM-A1 conferred protection against the development of intestinal inflammation and attenuated Th17 cell differentiation. Hence, the observed immunomodulatory effects of CORM-A1 could be useful for developing novel therapeutic approaches for managing intestinal inflammation through the regulation of Th17 differentiation.

Keywords: Carbon monoxide; Th17 differentiation; colitis.

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