Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Jul;68(7):425-430.
doi: 10.1111/pin.12677. Epub 2018 Apr 25.

Coexistence of Glandular Papilloma and Sclerosing Pneumocytoma in the Bronchiole

Affiliations
Case Reports

Coexistence of Glandular Papilloma and Sclerosing Pneumocytoma in the Bronchiole

Yuko Kitawaki et al. Pathol Int. .

Abstract

Both glandular papilloma (GP) and sclerosing pneumocytoma (SP) are rare tumors in the lung. We herein report an extremely rare case of coexistence of these two uncommon tumors. The patient was a 40-year-old Japanese woman with no chief complaint. A solitary nodule of the lung was detected using chest computed tomography. The transbronchial biopsy revealed that the tumor histologically corresponded to GP. The patient subsequently underwent partial resection of the right upper lobe. Histological examination of the resected specimens further revealed that the mass contained two different and independent elements and displayed typically histological features of GP and SP. Molecular analysis further revealed the presence of BRAF V600E and AKT1 E17K mutations in GP, whereas only AKT1 mutation was detected in SP. To our knowledge, this is the first case of coexistence of GP and SP in the bronchiole harboring common AKT1 mutation and different BRAF V600E mutational status.

Keywords: AKT1; BRAF; glandular papilloma; lung; p16; sclerosing pneumocytoma.

Similar articles

See all similar articles

Cited by 1 article

Publication types

Feedback