The Dilemma of Aneuploidy Screening on Low Responders

Curr Opin Obstet Gynecol. 2018 Jun;30(3):179-184. doi: 10.1097/GCO.0000000000000449.

Abstract

Purpose of review: Preimplantation genetic testing for aneuploidy (PGT-A) has been demonstrated to improve implantation and pregnancy rates and decrease miscarriage rates over standard morphology-based embryo selection. However, there are limited data on its efficacy in patients with diminished ovarian reserve or a poor response to stimulation who may have fewer embryos to select amongst.

Recent findings: Early findings demonstrate that PGT-A reduces the miscarriage rate and decreases the time to delivery in poor responders. These studies highlight the importance of designing trials that compare outcomes over multiple cycles as the benefit of PGT-A in this patient population lies in eliminating the time lost to futile transfers of aneuploid embryos. Furthermore, recent studies have demonstrated that a catch-all category of 'poor responder' may need to be reevaluated as different subpopulations of patients with low response exhibit different clinical characteristics.

Summary: More information is needed on characterizing the physiology of ovarian aging across multiple phenotypes of diminished ovarian reserve and establishing the predictive value of aneuploid results across multiple PGT-A platforms. However, initial data suggests benefit of PGT-A in poor responders.

Publication types

  • Review

MeSH terms

  • Aneuploidy*
  • Blastocyst / physiology*
  • Chromosome Disorders / diagnosis
  • Chromosome Disorders / genetics*
  • Female
  • Fertilization in Vitro
  • Genetic Testing*
  • Humans
  • Infertility, Female / therapy*
  • Ovarian Reserve / physiology*
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Rate
  • Preimplantation Diagnosis
  • Treatment Failure