The hydrolysis of ATP that accompanies actin polymerization is essentially irreversible

FEBS Lett. 1988 Aug 1;235(1-2):211-4. doi: 10.1016/0014-5793(88)81264-x.


The hydrolysis of ATP that accompanies the polymerization of actin occurs on the F-actin subsequent to the addition of the G-ATP-actin subunit to the elongating filament. We now show that this ATP hydrolysis is essentially irreversible. Thus, a large decrease in free energy occurs at the cleavage step, F-ATP-actin----F-ADP-Pi-actin.

MeSH terms

  • Actins / metabolism*
  • Adenosine Triphosphate / metabolism*
  • Animals
  • Calcium-Transporting ATPases / metabolism
  • Hydrolysis
  • Phosphates / metabolism
  • Polymers
  • Rabbits


  • Actins
  • Phosphates
  • Polymers
  • Adenosine Triphosphate
  • Calcium-Transporting ATPases