Associations Between Persistent Organic Pollutants and Metabolic Syndrome in Morbidly Obese Individuals

Nutr Metab Cardiovasc Dis. 2018 Jul;28(7):735-742. doi: 10.1016/j.numecd.2018.03.004. Epub 2018 Mar 13.

Abstract

Background and aims: Persons with "metabolically healthy" obesity may develop cardiometabolic complications at a lower rate than equally obese persons with evident metabolic syndrome. Even morbidly obese individuals vary in risk profile. Persistent organic pollutants (POPs) are widespread environmental chemicals that impair metabolic homeostasis. We explored whether prevalence of metabolic syndrome in morbidly obese individuals is associated with serum concentrations of POPs.

Methods and results: A cross-sectional study among 161 men and 270 women with BMI >35 kg/m2 and comorbidity, or >40 kg/m2. Circulating concentrations of 15 POPs were stratified by number of metabolic syndrome components. In multiple logistic regression analysis odds ratios between top quartile POPs and metabolic risk factors versus POPs below the top quartile were calculated adjusting for age, gender, body mass index, smoking status, alcohol consumption and cholesterol concentrations. Age-adjusted concentrations of trans-nonachlor and dioxin-like and non-dioxin-like polychlorinated biphenyls (PCBs) increased with number of metabolic syndrome components in both genders (p < 0.001), while the organochlorine pesticides HCB, β-HCH and p,p'DDE increased only in women (p < 0.008). Organochlorine pesticides in the top quartile were associated with metabolic syndrome as were dioxin-like and non-dioxin-like PCBs (OR 2.3 [95% CI 1.3-4.0]; OR 2.5 [95% CI 1.3-4.8] and 2.0 [95% CI 1.1-3.8], respectively). Organochlorine pesticides were associated with HDL cholesterol and glucose (OR = 2.0 [95% CI = 1.1-3.4]; 2.4 [95% CI = 1.4-4.0], respectively). Dioxin-like PCBs were associated with diastolic blood pressure, glucose and homeostatic model assessment-insulin resistance index (OR = 2.0 [95% CI = 1.1-3.6], 2.1 [95% CI = 1.2-3.6] and 2.1 [95% CI = 1.0-4.3], respectively).

Conclusion: In subjects with morbid obesity, metabolic syndrome was related to circulating levels of organochlorine pesticides and PCBs suggesting that these compounds aggravate clinically relevant complications of obesity.

Keywords: Insulin resistance; Metabolic syndrome; Morbid obesity; POPs.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cross-Sectional Studies
  • Environmental Exposure / adverse effects*
  • Environmental Pollutants / adverse effects*
  • Environmental Pollutants / blood
  • Female
  • Humans
  • Hydrocarbons, Chlorinated / adverse effects
  • Hydrocarbons, Chlorinated / blood
  • Male
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / chemically induced*
  • Metabolic Syndrome / diagnosis
  • Metabolic Syndrome / epidemiology*
  • Middle Aged
  • Norway / epidemiology
  • Obesity, Morbid / blood
  • Obesity, Morbid / diagnosis
  • Obesity, Morbid / epidemiology*
  • Organic Chemicals / adverse effects*
  • Organic Chemicals / blood
  • Polychlorinated Biphenyls / adverse effects
  • Polychlorinated Biphenyls / blood
  • Prevalence
  • Prognosis
  • Risk Assessment
  • Risk Factors
  • Young Adult

Substances

  • Environmental Pollutants
  • Hydrocarbons, Chlorinated
  • Organic Chemicals
  • Polychlorinated Biphenyls