Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine in Pain Reduction and Functional Capacity in Osteoarthritis Patients

J Diet Suppl. 2019;16(4):379-389. doi: 10.1080/19390211.2018.1461726. Epub 2018 Apr 27.


This observational, open, multicenter clinical trial with a single treatment group aimed to evaluate the effectiveness of a dietary supplement whose main ingredients are hydrolyzed gelatin, chondroitin sulfate, glucosamine sulfate, and devil's claw and bamboo extracts for pain reduction and improvement of functional capacities in patients with osteoarthritis (OA) of the knee and/or hip (REDART study). In all, 130 patients with OA recruited from Spanish hospitals received the dietary supplement for 6 months. The primary outcome was the patients' global assessment of pain in the affected joint as measured with a visual analogue scale (VAS). Other outcome measurements included the Lequesne Functional Index (subindexes for pain/discomfort, distance walked, and daily living) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC; subindexes for pain, stiffness, and physical function). Scores were taken at months 3 and 6 of the treatment. Patients (N = 78) showed a reduction of pain of 3.77 ± 1.77 points after 6 months (p < .0001) in the VAS. The total reduction in the Lequesne Functional Index was 6.30 ± 4.08 points after 6 months (p < .0001), with significant reductions in all subindexes of the scale. A similar pattern was found for the WOMAC index, with an overall reduction of 22.49 ± 14.03 points after 6 months (p < .0001) and significant reductions in all subindexes. No major adverse events were noted during the treatment. This exploratory study shows that treatment with the dietary supplement significantly reduces pain and improves locomotor function in patients with OA of the knee and/or hip.

Keywords: chondroitin sulfate; devil's claw; glucosamine; osteoarthritis.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Observational Study

MeSH terms

  • Aged
  • Analgesics / administration & dosage*
  • Chondroitin Sulfates / administration & dosage*
  • Collagen / administration & dosage*
  • Dietary Supplements
  • Female
  • Glucosamine / administration & dosage*
  • Humans
  • Locomotion / drug effects
  • Male
  • Middle Aged
  • Osteoarthritis / drug therapy*
  • Osteoarthritis / physiopathology*
  • Osteoarthritis, Hip / drug therapy
  • Osteoarthritis, Hip / physiopathology
  • Osteoarthritis, Knee / drug therapy
  • Osteoarthritis, Knee / physiopathology
  • Pain Measurement
  • Spain
  • Treatment Outcome


  • Analgesics
  • Chondroitin Sulfates
  • Collagen
  • Glucosamine