The snowball effect of RNA binding protein dysfunction in amyotrophic lateral sclerosis

Brain. 2018 May 1;141(5):1236-1238. doi: 10.1093/brain/awy091.


This scientific commentary refers to ‘TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis’, by Deshaies et al. (doi:10.1093/brain/awy062).

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Alternative Splicing
  • Amyotrophic Lateral Sclerosis*
  • DNA-Binding Proteins / genetics
  • Heterogeneous Nuclear Ribonucleoprotein A1
  • Humans
  • RNA-Binding Proteins


  • DNA-Binding Proteins
  • Heterogeneous Nuclear Ribonucleoprotein A1
  • RNA-Binding Proteins
  • TARDBP protein, human