Pattern of polyphenol intake and the long-term risk of dementia in older persons

Neurology. 2018 May 29;90(22):e1979-e1988. doi: 10.1212/WNL.0000000000005607. Epub 2018 Apr 27.


Objective: To investigate the optimal combination of dietary polyphenols associated with the long-term risk of dementia in a large prospective French cohort of older persons, the Three-City (3C) Study.

Methods: We included 1,329 older adults without dementia from the 3C study with assessment of intake of 26 polyphenol subclasses who were followed up for 12 years for dementia. Using partial least squares for Cox models, we identified a pattern of polyphenol intake associated with dementia risk.

Results: The pattern combined several flavonoids (dihydroflavonols, anthocyanins, isoflavonoids, flavanones), stilbenes (including resveratrol), lignans, and other subclasses (hydroxybenzaldehydes, naphthoquinones, furanocoumarins). Compared with participants in the lower quintile of pattern score, those in the higher quintile had a 50% lower risk of dementia (95% confidence interval 20%-68%, p for trend <0.01) in multivariate models.

Conclusions: In this French cohort, a polyphenol pattern provided by a diet containing specific plant products (nuts, citrus, berries, leafy vegetables, soy, cereals, olive oil) accompanied by red wine and tea was associated with lower dementia risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Dementia / prevention & control*
  • Diet*
  • Female
  • France
  • Humans
  • Male
  • Polyphenols*
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors


  • Polyphenols