The barberry juice effects on metabolic factors and oxidative stress in patients with type 2 diabetes: A randomized clinical trial

Complement Ther Clin Pract. 2018 May;31:170-174. doi: 10.1016/j.ctcp.2018.01.009. Epub 2018 Feb 17.

Abstract

Aim: The aim of this study was to investigate the effect of barberry juice (BJ) on cardiovascular risk factors in patients with type 2 diabetes (T2DM).

Methods: 46 diabetic Patients were randomly allocated to either the BJ group (n = 23) who consumed 200 ml of BJ daily for eight weeks, or the control group (n = 23) with no intervention. At the baseline and the end of 8-week intervention, blood pressure and biochemical markers were measured.

Results: forty-two Patients completed the study. After intervention systolic blood pressure (SBP), diastolic blood pressure (DBP), Fasting Blood Sugar (FBS) Total Cholesterol significantly decreased (P < 0.05 for treatment effect) also Triglyceride (TG) decrease significantly in BJ group. Paraoxonase-1(PON1) concentrations significantly increased in Bj group and have a significant difference (P < 0.0001 for treatment effect) compared with control group.

Conclusions: This study revealed that BJ might decrease the risk of cardiovascular diseases in patients with diabetes.

Keywords: Barberry; Metabolic factor; Oxidative stress; Type 2 diabetes.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aryldialkylphosphatase / blood*
  • Berberis*
  • Blood Glucose / metabolism*
  • Blood Pressure / drug effects
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / prevention & control
  • Cholesterol / blood
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Diabetes Mellitus, Type 2 / metabolism
  • Female
  • Fruit
  • Humans
  • Lipids / blood*
  • Male
  • Middle Aged
  • Oxidative Stress / drug effects*
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Triglycerides / blood

Substances

  • Blood Glucose
  • Lipids
  • Plant Extracts
  • Triglycerides
  • Cholesterol
  • Aryldialkylphosphatase
  • PON1 protein, human