Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells

Nature. 1988 Sep 15;335(6187):229-33. doi: 10.1038/335229a0.


T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing alpha and beta T-cell receptor genes isolated from a male-specific, H-2Db-restricted CD4-8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens determines the differentiation of CD4+8+ thymocytes into either CD4+8- or CD4-8+ mature T cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Differentiation*
  • Cell Differentiation
  • Female
  • H-2 Antigens
  • Mice
  • Mice, Transgenic
  • Phenotype
  • Receptors, Antigen, T-Cell*
  • Selection, Genetic
  • T-Lymphocytes / physiology*
  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocytes, Regulatory


  • Antigens, Differentiation
  • H-2 Antigens
  • Receptors, Antigen, T-Cell