Causes of death to age 30 in Down syndrome

Am J Hum Genet. 1988 Sep;43(3):239-48.


To look at the underlying cause of death (U.C.O.D.) data for Down syndrome (DS), we studied 324 DS individuals who died out of a total of 1,337 DS births occurring in 1,066,508 consecutive live births during the years 1952-81 inclusive. U.C.O.D. rates, separated into ICD-9 classifications, for the DS population were compared with those of the age-matched general population. In general, an individual with DS is significantly more likely to die than the age-matched general population over all ages studied up to age 30. The greatest absolute likelihood of dying is under 1 year, but the age group with the greatest relative risk of dying (17.2) is very definitely between ages 1-9. In order, the three categories for causes of death in DS with the greatest relative risk are congenital anomalies, circulatory system, and respiratory system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Accidents
  • Age Factors
  • British Columbia
  • Cardiovascular Diseases / complications
  • Communicable Diseases / complications
  • Digestive System Diseases / complications
  • Down Syndrome / complications
  • Down Syndrome / mortality*
  • Endocrine System Diseases / complications
  • Hematologic Diseases / complications
  • Humans
  • Intellectual Disability / complications
  • Neoplasms / complications
  • Nervous System Diseases / complications
  • Respiration Disorders / complications
  • Risk Factors