Angiopoietin-2 level as a tool for cardiovascular risk stratification in hypertensive type 2 diabetic subjects

Postgrad Med. 2018 May;130(4):402-408. doi: 10.1080/00325481.2018.1469370. Epub 2018 May 8.


Objectives: This observational cross-sectional study aimed to investigate the relationship between serum Angiopoietin-2 (Ang-2) levels and cardiovascular (CVD) risk factors in drug controlled hypertensive diabetic subjects without cardiovascular complications.

Methods: All subjects were evaluated for fasting blood glucose (FBG), HbA1c, liver enzymes, lipid profile and serum Ang-2.

Results: Mean serum Ang-2 level was significantly higher in hypertensive diabetic subjects. In bivariate analysis in diabetic subjects with cardiovascular risk factors, Ang-2 positively correlated with waist circumference, body mass index (BMI), systolic blood pressure (SBP), FBG, HbA1c and triglycerides. In multivariate linear regression analysis, this association remained significant with FBG and triglycerides. Ang-2 levels were independently associated with CVD risk factors in drug controlled Type 2 diabetes (T2D) subjects.

Conclusions: Further detailed studies in larger population with more attention is needed to consider Ang-2 level as a tool for CVD risk stratification in hypertensive diabetic subjects.

Keywords: Angiopoietin 2; angiogenesis; cardiovascular diseases; hypertension; microvascular complications; type 2 diabetes.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Angiopoietin-2 / metabolism*
  • Antihypertensive Agents
  • Blood Glucose / metabolism
  • Blood Pressure
  • Body Mass Index
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / metabolism
  • Comorbidity
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / metabolism*
  • Female
  • Glycated Hemoglobin / metabolism
  • Humans
  • Hypertension / drug therapy
  • Hypertension / epidemiology
  • Hypertension / metabolism*
  • Hypoglycemic Agents / therapeutic use
  • Linear Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Prognosis
  • Risk Assessment
  • Risk Factors
  • Triglycerides / metabolism
  • Waist Circumference


  • ANGPT2 protein, human
  • Angiopoietin-2
  • Antihypertensive Agents
  • Blood Glucose
  • Glycated Hemoglobin A
  • Hypoglycemic Agents
  • Triglycerides
  • hemoglobin A1c protein, human