Turning Cold Tumors Hot by Blocking TGF-β

Trends Cancer. 2018 May;4(5):335-337. doi: 10.1016/j.trecan.2018.03.005. Epub 2018 Mar 30.


Novel immune therapeutic tools are rapidly expanding the anticancer arsenal. Despite this progress, patients with colorectal cancer (CRC) that spreads to vital parts of the body still have a dismal outcome. Transforming growth factor-β (TGF-β) plays a pivotal role in the development of CRC and metastasis. Important new work by Tauriello and colleagues has revealed that inhibition of TGF-β prevents tumor metastasis by enhancing a cytotoxic T cell response, suggesting that TGF-β inhibition is a promising pro-immunogenic therapy.

Keywords: CMS4; TGF-β; colorectal cancer; immunotherapy; mesenchymal subtype; metastasis.

Publication types

  • Comment

MeSH terms

  • Colonic Neoplasms
  • Colorectal Neoplasms
  • Humans
  • Immune Evasion*
  • Signal Transduction
  • Transforming Growth Factor beta*


  • Transforming Growth Factor beta