Noninvasive PET Imaging of T cells

Weijun Wei; Dawei Jiang; Emily B Ehlerding; Quanyong Luo; Weibo Cai

doi:10.1016/j.trecan.2018.03.009

Noninvasive PET Imaging of T cells

Trends Cancer. 2018 May;4(5):359-373. doi: 10.1016/j.trecan.2018.03.009. Epub 2018 Apr 17.

Authors

Weijun Wei¹, Dawei Jiang², Emily B Ehlerding³, Quanyong Luo⁴, Weibo Cai⁵

Affiliations

¹ Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Department of Radiology, Department of Medical Physics, University of Wisconsin, Madison, WI 53705, USA; These authors contributed equally to this work.
² Department of Radiology, Department of Medical Physics, University of Wisconsin, Madison, WI 53705, USA; These authors contributed equally to this work.
³ Department of Medical Physics, University of Wisconsin, Madison, WI 53705, USA.
⁴ Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China. Electronic address: lqyn@sh163.net.
⁵ Department of Radiology, Department of Medical Physics, University of Wisconsin, Madison, WI 53705, USA; Department of Medical Physics, University of Wisconsin, Madison, WI 53705, USA; University of Wisconsin Carbone Cancer Center, Madison, Wisconsin 53705, USA. Electronic address: wcai@uwhealth.org.

Abstract

The rapidly evolving field of cancer immunotherapy recently saw the approval of several new therapeutic antibodies. Several cell therapies, for example, chimeric antigen receptor-expressing T cells (CAR-T), are currently in clinical trials for a variety of cancers and other diseases. However, approaches to monitor changes in the immune status of tumors or to predict therapeutic responses are limited. Monitoring lymphocytes from whole blood or biopsies does not provide dynamic and spatial information about T cells in heterogeneous tumors. Positron emission tomography (PET) imaging using probes specific for T cells can noninvasively monitor systemic and intratumoral immune alterations during experimental therapies and may have an important and expanding value in the clinic.

Keywords: T cells; cancer; graft-versus-host disease (GVHD); immunotherapy; inflammation; positron emission tomography (PET); response prediction.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Immunotherapy
Neoplasms / therapy
Positron-Emission Tomography*
Precision Medicine
T-Lymphocytes*

Abstract

Publication types

MeSH terms

Grants and funding