RETRACTED: Emodin attenuates apoptosis and inflammation induced by LPS through up-regulating lncRNA TUG1 in murine chondrogenic ATDC5 cells

Biomed Pharmacother. 2018 Jul:103:897-902. doi: 10.1016/j.biopha.2018.04.085. Epub 2018 Apr 24.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Concerns were raised about the background pattern of the Western Blots from Figures 4 and 5. Given the comments of Dr Elisabeth Bik regarding this article “This paper belongs to a set of over 400 papers (as per February 2020) that share very similar Western blots with tadpole-like shaped bands, the same background pattern, and striking similarities in title structures, paper layout, bar graph design, and - in a subset - flow cytometry panels”, the journal requested the authors to provide the raw data. However, the authors were not able to provide raw data of sufficient quality and detail for the journal to independently audit the provenance and validity of the data, and therefore the Editor-in-Chief decided to retract the article.

Keywords: Apoptosis; Emodin; Inflammatory response; Notch/NF-κB; Osteoarthritis; lncRNA TUG1.

Publication types

  • Retracted Publication

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Apoptosis / drug effects*
  • Apoptosis / genetics
  • Apoptosis Regulatory Proteins / metabolism
  • Cell Line
  • Cell Survival / drug effects
  • Cell Survival / genetics
  • Chondrocytes / drug effects*
  • Chondrocytes / immunology
  • Chondrocytes / pathology
  • Cytokines / genetics*
  • Emodin / pharmacology*
  • Inflammation
  • Lipopolysaccharides / toxicity
  • Mice
  • RNA, Long Noncoding / genetics*
  • Up-Regulation

Substances

  • Anti-Inflammatory Agents
  • Apoptosis Regulatory Proteins
  • Cytokines
  • Lipopolysaccharides
  • RNA, Long Noncoding
  • TUG1 noncoding RNA, mouse
  • Emodin