Sparse feature learning for multi-class Parkinson's disease classification

Technol Health Care. 2018;26(S1):193-203. doi: 10.3233/THC-174548.


This paper solves the multi-class classification problem for Parkinson's disease (PD) analysis by a sparse discriminative feature selection framework. Specifically, we propose a framework to construct a least square regression model based on the Fisher's linear discriminant analysis (LDA) and locality preserving projection (LPP). This framework utilizes the global and local information to select the most relevant and discriminative features to boost classification performance. Differing in previous methods for binary classification, we perform a multi-class classification for PD diagnosis. Our proposed method is evaluated on the public available Parkinson's progression markers initiative (PPMI) datasets. Extensive experimental results indicate that our proposed method identifies highly suitable regions for further PD analysis and diagnosis and outperforms state-of-the-art methods.

Keywords: Parkinson’s disease; classification; feature selection; multi-class.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Algorithms
  • Biomarkers
  • Brain Mapping / methods*
  • Brain Mapping / statistics & numerical data
  • Disease Progression*
  • Female
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Learning / classification*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / physiopathology*


  • Biomarkers