Organocatalyzed Synthesis of [3.2.1] Bicyclooctanes

Molecules. 2018 Apr 28;23(5):1039. doi: 10.3390/molecules23051039.


Organocatalysis constitutes one of the main research areas in organic chemistry from the last two decades. This chemistry has been applied to the synthesis of many natural products and structures in a manner that reduces the residues and so the ecological impact. In this review, we consider the work that has been done for the synthesis of bicyclo[3.2.1]octane framework. This structure is present in many natural products with very important biological activities.

Keywords: bicycle; bicyclo[3.2.1]; organocatalysis.

Publication types

  • Review

MeSH terms

  • Biological Products / chemistry*
  • Catalysis
  • Cyclooctanes / chemical synthesis*
  • Cyclooctanes / chemistry
  • Molecular Structure
  • Organic Chemistry Phenomena
  • Stereoisomerism


  • Biological Products
  • Cyclooctanes