An Access to Glycoconjugate Libraries through Multicomponent Reactions

Oswald Lockhoff

doi:10.1002/(SICI)1521-3773(19981231)37:24<3436::AID-ANIE3436>3.0.CO;2-Z

An Access to Glycoconjugate Libraries through Multicomponent Reactions

Angew Chem Int Ed Engl. 1998 Dec 31;37(24):3436-3439. doi: 10.1002/(SICI)1521-3773(19981231)37:24<3436::AID-ANIE3436>3.0.CO;2-Z.

Author

Oswald Lockhoff¹

Affiliation

¹ Bayer AG, Central Research, ZF-WF Q18, D-51368 Leverkusen (Germany), Fax: (+49) 214-3050070.

Abstract

Four-component reactions: The Ugi reaction of four suitably functionalized carbohydrate derivatives (as a per-O-benzylated amine, an aldehyde, a carboxylic acid, and an isocyanide) allow the effective assembly of diverse compound libraries. The complex glycoconjugates formed can be deprotected (see the picture for an example), and the resulting glycomimetics are of high interest for screening purposes.

Keywords: Carbohydrates; Combinatorial chemistry; Glycoconjugates; Glycomimetics; Multicomponent reactions.