Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes

Nature. 1988 Oct 6;335(6190):519-25. doi: 10.1038/335519a0.


The c-mos proto-oncogene is expressed as a maternal mRNA in oocytes and early embryos of Xenopus laevis, but its translation product pp39mos is detectable only during progesterone-induced oocyte maturation. Microinjection of mos-specific antisense oligonucleotides into oocytes not only prevents expression of pp39mos, but also blocks germinal vesicle breakdown, indicating that it functions during reinitiation of meiotic division.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • DNA
  • Female
  • Meiosis*
  • Mitosis
  • Molecular Sequence Data
  • Oncogenes
  • Oocytes / growth & development*
  • Proto-Oncogene Proteins / physiology*
  • Proto-Oncogene Proteins c-mos
  • Xenopus / embryology*


  • Proto-Oncogene Proteins
  • DNA
  • Proto-Oncogene Proteins c-mos

Associated data