From Structural Models of Galactose Oxidase to Homogeneous Catalysis: Efficient Aerobic Oxidation of Alcohols

Phalguni Chaudhuri; Martina Hess; Ulrich Flörke; Karl Wieghardt

doi:10.1002/(SICI)1521-3773(19980904)37:16<2217::AID-ANIE2217>3.0.CO;2-D

From Structural Models of Galactose Oxidase to Homogeneous Catalysis: Efficient Aerobic Oxidation of Alcohols

Angew Chem Int Ed Engl. 1998 Sep 4;37(16):2217-2220. doi: 10.1002/(SICI)1521-3773(19980904)37:16<2217::AID-ANIE2217>3.0.CO;2-D.

Authors

Phalguni Chaudhuri¹, Martina Hess¹, Ulrich Flörke², Karl Wieghardt¹

Affiliations

¹ Max-Planck-Institut für Strahlenchemie, Stiftstrasse 34-36, 45470 Mülheim an der Ruhr (Germany), Fax: (+49) 208-306-3952.
² Anorganische und Analytische Chemie, Universität-Gesamthochschule Paderborn (Germany).

Abstract

Two reaction pathways are catalyzed by the dinuclear copper(II)-phenoxyl complex 1-a functional model for the metalloenzyme galactose oxidase-by the oxidation of primary and secondary alcohols with dioxygen (air) in homogeneous solution to their corresponding aldehydes or ketones and/or 1,2-glycols (oxidative C-C coupling). The reduction product formed is H₂ O₂ , not water.

Keywords: Alcohols; Copper; Galactose oxidase; Homogeneous catalysis; Metalloenzymes.